Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior

Positron emission tomography (PET) imaging consistently shows blunted striatal dopamine release and decreased dopamine D2 receptor availability in addiction. Here, we review the preclinical and clinical studies indicating that this neurobiological phenotype is likely to be both a consequence of chronic drug consumption and a vulnerability factor in the development of addiction. We propose that, behaviorally, blunted striatal dopamine transmission could reflect the increased impulsivity and altered cost/benefit computations that are associated with addiction.

Source: Seminars in Nuclear Medicine - October 12, 2016 Category: Nuclear Medicine Authors: Pierre Trifilieff, Fabien Ducrocq, Suzanne van der Veldt, Diana Martinez Source Type: research