Inhibitory Effect of TLR4 Gene Silencing on Intimal Hyperplasia of Vein Grafting

Conclusion:
These results showed that local silencing of TLR4 in the vein grafts could inhibit intimal hyperplasia by downregulating the expression of inflammatory factors in the vein grafts, suggesting that TLR4 can be used as a new target for therapy of vascular intimal hyperplasia.

Source: Vascular and Endovascular Surgery - October 11, 2016 Category: Surgery Authors: Zhu, Z., Xu, R., Zheng, X., Wang, T., Li, D., Wang, Y., Liu, K. Tags: Original Manuscripts Source Type: research