Biomarkers of Key Biological Pathways in CVD

This review provides background on the laboratory design for MESA (Multi-Ethnic Study of Atherosclerosis) as well as the approach used in MESA to select biomarkers for measurement. The research related to the multitude of circulating and urinary biomarkers of inflammation and other novel and emerging biological pathways in MESA is summarized by domain, or pathway, represented by the biomarker. The contributions of MESA biomarkers to our knowledge of these key pathways in the development and progression of atherosclerosis, cardiovascular disease, diabetes, kidney disease, and pulmonary disease are highlighted, as are the contributions of MESA to recommendations for clinical use of several of these biomarkers.

Source: CVD Prevention and Control - August 31, 2016 Category: Cardiology Authors: Nancy Swords Jenny, Nels C. Olson, Matthew A. Allison, Dena E. Rifkin, Lori B. Daniels, Ian H. de Boer, Christina L. Wassel, Russell P. Tracy Tags: Review Source Type: research