Blockade of dorsal hippocampal orexin-1 receptors impaired morphine- induced state-dependent learning

Behavioral abnormalities associated with opiate addiction include memory and learning deficits, which are the result of some alterations in the neuromodulatory systems. Recently, orexin has shown to influence drug addiction neural circuitry, specifically in mediating reward-related perception and memory. To explore the possible interaction of orexinergic and opioidergic system on modulation of learning and memory, we have investigated the effects of intra-dorsal hippocampal (intra-CA1) administration of orexin-1 receptor agonist and the competitive orexin-1 antagonist, SB-334,867, on morphine-induced memory impairment by using step-down passive avoidance task in mice.

Source: Neuropeptides - October 10, 2016 Category: Neuroscience Authors: Maryam Farahmandfar, Mehdi Kadivar, Sareh Rastipisheh Source Type: research