Vitamin E and caloric restriction promote hepatic homeostasis through expression of connexin 26, N-cad, E-cad, and cholesterol metabolism genes

Connexins (Cx) and cadherins (cad) are responsible for cell homeostasis. The Cx activity is directly related to cholesterol. The present work investigates whether vitamin E, with or without caloric restriction (CR), alters the mRNA expression of Cx26, Cx32, Cx43, N-cad, E-cad and α-SMA, and evaluates their relation to cholesterol metabolism in rat liver. Animals were divided into different groups: control with ad libitum diet (C); control + vitamin E (CV); caloric restriction to 60% of the intake of group C (CR); and the intake of group CR+vitamin E (RV).

Source: The Journal of Nutritional Biochemistry - October 10, 2016 Category: Biochemistry Authors: Leonardo Vin ícius Santolim, Maria Esméria Corezola do Amaral, José Luís Fachi, Maíra Felonato Mendes, Camila Andréa de Oliveira Source Type: research