Deletion of liver-specific STAT5 gene alters the expression of bile acid metabolism genes and reduces liver damage in lithogenic diet-fed mice

Signal transducers and activators of transcription 5 (STAT5) mediates growth hormone (GH) signals, which may control hepatic cholesterol uptake and bile acid metabolism. Deregulation of liver cholesterol homeostasis and bile acid metabolism may cause liver damage and cholesterol gallstone development. The purpose of this study was to understand the role of local STAT5 signaling in cholesterol and bile acid metabolism using liver-specific STAT5 knock-out (STAT5 LKO) mice on a normal diet and a cholesterol- and bile acid-containing lithogenic diet.

Source: The Journal of Nutritional Biochemistry - October 10, 2016 Category: Biochemistry Authors: Myunggi Baik, Jangseon Kim, Min Yu Piao, Hyeok Joong Kang, Seung Ju Park, Sang Weon Na, Sung-Hoon Ahn, Jae-Hyuk Lee Source Type: research