Maternal obesity mediated predisposition to respiratory complications at birth and in later life: understanding the implications of the obesogenic intrauterine environment

More women than not are entering pregnancy either overweight or obese. This presents a significant health care burden with respect to maternal morbidities and offspring complications at birth and in later life. In recent years it has also become clear that maternal obesity is an even greater global health problem than anticipated, because the effects are not limited to the mother but are also programmed in the fetus, known as the ‘intergenerational cycle of obestiy’. Despite a large body of epidemiological evidence reporting outcomes of obese pregnancies, including offspring respiratory complications, much less is known about the molecular effects of maternal obesity on fetal lung development.

Source: Paediatric Respiratory Reviews - October 10, 2016 Category: Respiratory Medicine Authors: Erin V. McGillick, Mitchell C. Lock, Sandra Orgeig, Janna L. Morrison Source Type: research