Pharmacogenetic Analysis of Functional Glutamate System Gene Variants and Clinical Response to Clozapine

We report no significant associations following correction for multiple testing. Prior to correction, nominally significant associations were observed forSLC6A9,SLC1A2,GRM2, andGRIA1. Most notably, CC homozygotes of rs16831558 located in the glycine transporter 1 gene(SLC6A9) exhibited an allele dose-dependent improvement in positive symptoms compared to T allele carriers (puncorrected = 0.008, pcorrected = 0.08). To clarify the role ofSLC6A9 in clinical response to antipsychotic medication, and CLZ in particular, this finding warrants further investigation in larger well-characterized samples.Mol Neuropsychiatry 2016;2:185-197

Source: Molecular Neuropsychiatry - October 11, 2016 Category: Neuroscience Source Type: research