Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: Protection associated with mycobacterial antigen-specific CD4 effector memory T-cell populations

This study compares the immunogenicity and efficacy of BCG administered by ID and intravenous (IV) injection, or as an intratracheal mucosal boost (ID  + IT), against aerosol challenge with Mycobacterium tuberculosis Erdman strain. Disease pathology was significantly reduced, and survival improved, by each BCG vaccination strategy, relative to unvaccinated animals.

Source: Tuberculosis - October 6, 2016 Category: Respiratory Medicine Authors: S. Sharpe, A. White, C. Sarfas, L. Sibley, F. Gleeson, A. McIntyre, R. Basaraba, S. Clark, G. Hall, E. Rayner, A. Williams, P.D. Marsh, M. Dennis Tags: Model Systems Source Type: research