Anti-inflammatory effects of Bifidobacterium longum subsp infantis secretions on fetal human enterocytes are mediated by TLR-4 receptors

This study suggests that PCM may use TLR-4 through IRAK-2 and via AP-1 to prevent IL-1β-induced IL-6 induction in immature enterocytes. Based on these observations, the combined use of probiotics and anti-TLR-4 therapy to prevent NEC may not be a good strategy.

Source: AJP: Gastrointestinal and Liver Physiology - October 6, 2016 Category: Gastroenterology Authors: Meng, D., Zhu, W., Ganguli, K., Shi, H. N., Walker, W. A. Tags: MICROBIOME AND HOST INTERACTIONS Source Type: research