Preterm delivery and associated negative pregnancy outcome – A tale of faulty progesterone receptor signalling pathway and linked derailed immunomodulation: A study from Northeast India

The duration of human pregnancy is critical for fetal maturation (Lindstrom and Bennett, 2005); but is sometimes compromised by a number of complications, such as threatened abortion, recurrent spontaneous miscarriage, preeclampsia, and preterm delivery leading to fetal mortality or morbidity. Delivery occurring before 37 weeks of gestation is referred to as preterm delivery, which is a global problem and is the prime cause of prenatal morbidity and mortality (Beck et al., 2010). India has the highest prevalence rate of preterm delivery (Blencowe et al., 2012), and alarmingly high rate has been reported from the North-eastern region of India which has an ethnically distinct tribal dominant population (Gogoi and Prusty, 2013; Tiwari et al., 2015).
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research