Immunosuppression for Kidney Transplantation: Where are we now and where are we going?

Advances in immunosuppression have propelled kidney transplantation from a scientific curiosity to the optimal treatment for patients with end stage kidney disease. Declining rates of acute rejection have led to improvements in shorter-term kidney transplant survival, culminating in incrementally better longer-term patient and allograft outcomes. Contextualized around established immune-suppressing drug targets, this review summarizes the history of the clinical science, and highlights the pivotal trials that have led to present-day treatment standards at the level of both individual agents as well as multidrug regimens for kidney recipients.
Source: Transplantation Reviews - Category: Transplant Surgery Authors: Source Type: research