Dietary calcium supplementation in adult rats reverts Brown adipose tissue dysfunction programmed by postnatal early overfeeding

Brown adipose tissue (BAT) dysfunction is associated with obesity and its co-morbidities, such as hypertension, and the improvement of BAT function seems important for obesity management. Here we investigated the effects of dietary calcium supplementation on BAT autonomic nerve activity, sympathoadrenal function and cardiovascular parameters in adult obese rats that were raised in small litters (SL group). Three days after birth, SL litters were adjusted to 3 pups to induce early overfeeding. The control group remained with 10 pups/litter until weaning (NL group).

Source: The Journal of Nutritional Biochemistry - October 9, 2016 Category: Biochemistry Authors: E.P.S. Concei ção, E.G. Moura, E. Oliveira, D.S. Guarda, M.S. Figueiredo, F.T. Quitete, C. Calvino, R.A. Miranda, P.C.F. Mathias, A.C. Manhães, P.C. Lisboa Source Type: research