Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy

Conclusion:
Nicorandil protects against stress-induced cell death in dystrophin-deficient cardiomyocytes and preserves cardiac function in the mdx mouse heart subjected to ischemia and reperfusion injury. This suggests a potential therapeutic role for nicorandil in dystrophin-deficient cardiomyopathy.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - October 4, 2016 Category: Cardiology Authors: Afzal, M. Z., Reiter, M., Gastonguay, C., McGivern, J. V., Guan, X., Ge, Z.-D., Mack, D. L., Childers, M. K., Ebert, A. D., Strande, J. L. Tags: Experimental Studies Source Type: research