Volume regulatory hormones and plasma volume in pregnant women with sickle cell disorder

Conclusions:
The lower plasma renin concentration at 16 weeks with HbSS could be either primary or secondary to vasoconstriction related to inadequate vasodilator activity. The contracted plasma volume might then stimulate aldosterone synthesis by non-angiotensin II dependent stimulation. Studies of vasodilators such as nitric oxide, vasodilator eicosanoids or the PlGF/VEGF/sFlT-1 axis in pregnant HbSS and HbAA women will test this hypothesis.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 26, 2016 Category: Biomedical Science Authors: Afolabi, B. B., Oladipo, O. O., Akanmu, A. S., Abudu, O. O., Sofola, O. A., Broughton Pipkin, F. Tags: Original Article Source Type: research