Editors Highlight: Neonatal Activation of the Xenobiotic-Sensors PXR and CAR Results in Acute and Persistent Down-regulation of PPAR{alpha}-Signaling in Mouse Liver

In conclusion, neonatal exposure to PXR- and CAR-activators both acutely and persistently regulates critical genes involved in xenobiotic and lipid metabolism in liver.

Source: Toxicological Sciences - September 25, 2016 Category: Toxicology Authors: Li, C. Y., Cheng, S. L., Bammler, T. K., Cui, J. Y. Tags: PXR, CAR, and Downregulation of PPARa Signaling Source Type: research