High cut-off dialysis in chronic haemodialysis patients reduces serum procalcific activity

Conclusions The use of HCO dialysis membranes in chronic dialysis patients reduces the procalcific effects of serum on VSMC in vitro. The mechanisms of the strong effect of HCO on in vitro calcification are not completely understood. One factor may be lower levels of VCAM-1 in HCO serum samples, since VCAM-1 was able to induce vascular calcification in our experiments. Neither sTNFR 1, sTNFR 2 nor sIL2R enhance vascular calcification in vitro. Regardless of the mechanisms, our results encourage further studies of highly permeable filters in chronic dialysis patients.
Source: Nephrology Dialysis Transplantation - Category: Urology & Nephrology Authors: Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research