Micro-RNA analysis of renal biopsies in human lupus nephritis demonstrates up-regulated miR-422a driving reduction of kallikrein-related peptidase 4

Conclusions
KLK4, a serine esterase with putative renoprotective properties, is down-regulated by miR-422a in LN kidney suggesting that, in addition to immune activation, local factors may be implicated in the disease.

Source: Nephrology Dialysis Transplantation - September 27, 2016 Category: Urology & Nephrology Authors: Krasoudaki, E., Banos, A., Stagakis, E., Loupasakis, K., Drakos, E., Sinatkas, V., Zampoulaki, A., Papagianni, A., Iliopoulos, D., Boumpas, D. T., Bertsias, G. K. Tags: Chronic Kidney Disease Source Type: research