Functional Recovery in Osteoarthritic Chondrocytes Through Hyaluronic Acid and Platelet-Rich Plasma-Inhibited Infrapatellar Fat Pad Adipocytes

Conclusion:
IFP adipocyte–derived releasates mediated inflammatory response dedifferentiation in chondrocytes, which was recovered through HA+PRP administration.

Clinical Relevance:
Our findings demonstrated that HA+PRP effectively diminished IFP adipocyte–promoted inflammation in articular chondrocytes, indicating that the IFP could be a potential therapeutic target for OA therapy.

Source: The American Journal of Sports Medicine - September 29, 2016 Category: Sports Medicine Authors: Chen, W.-H., Lin, C.-M., Huang, C.-F., Hsu, W.-C., Lee, C.-H., Ou, K.-L., Dubey, N. K., Deng, W.-P. Tags: Growth factors/Healing enhancement, Knee, articular cartilage Biology and Translational Research Source Type: research