Insulin promotes proliferation and fibrosing responses in activated pancreatic stellate cells

In conclusion, our data support the concept that increased local glucose and insulin concentrations associated with obesity and T2DM promote PaSC growth and fibrosing responses.

Source: AJP: Gastrointestinal and Liver Physiology - September 30, 2016 Category: Gastroenterology Authors: Yang, J., Waldron, R. T., Su, H.-Y., Moro, A., Chang, H.-H., Eibl, G., Ferreri, K., Kandeel, F. R., Lugea, A., Li, L., Pandol, S. J. Tags: PANCREATIC PHYSIOLOGY/PATHOPHYSIOLOGY Source Type: research