Synthesis, Molecular Mechanism and Pharmacokinetic Studies of New Epoxy Lignan ‐Based Derivatives

The oxidative demethylation procedure for a new epoxy lignan isolated from Piper nigrum was applied to the synthesis of 3’‐methoxy‐3”,4”‐(methylenedioxy)‐2,5‐epoxylignan‐4’‐ol‐6’‐one. This compound inhibited the mRNA expression of the protein patched homolog (Ptch) in human pancreatic cancer cells (PANC1) and therefore might be valuable as a probe for tumor‐related disease. The pharmacokinetic profile of 3'‐methoxy‐3”,4”‐(methylenedioxy)‐2,5‐epoxylignan‐4'‐ol‐6'‐one was rapidly determined using ultra‐fast liquid chromatography. The compound was rapidly absorbed in blood. 3′‐Methoxy‐3″,4″‐(methylenedioxy)‐2,5‐epoxylignan‐4′‐ol‐6′‐one was derived from a new epoxy lignan isolated from Piper nigrum. The pharmacokinetic profile of this compound was determined using ultra‐fast liquid chromatography.
Source: Archiv der Pharmazie - Category: Drugs & Pharmacology Authors: Tags: Full Paper Source Type: research