Analysis of human leukocyte antigen genotypes in pemphigus with antidesmoglein antibody profile shift

In this study, we examined human leukocyte antigen (HLA) genotypes of four pemphigus patients who presented with the phenotypic transition and/or antibody profile shift. Two out of four patients possessed a DRB1*0405-DQB1*0401, and two out of four patients possessed a DRB1*1405-DQB1*0503. These alleles might be associated with the development of phenotypic transition and antibody profile shift.

Source: Dermatologica Sinica - October 1, 2016 Category: Dermatology Source Type: research