Genetic predisposition to colorectal cancer: Implications for treatment and prevention

Colorectal cancer (CRC) is the third most common cancer diagnosed in men and women and approximately 5% of cases are associated with identifiable germline mutations associated with hereditary cancer syndromes. Lifetime risks for CRC can approach 50% –80% for mutation carriers in the absence of endoscopic and/or surgical intervention, and early identification of at-risk individuals can guide clinical interventions for cancer prevention and treatment. Personal and family history and molecular phenotype of CRC tumors are used in determining whic h patients should be referred for clinical genetic evaluation.
Source: Seminars in Oncology - Category: Cancer & Oncology Authors: Source Type: research