Salsolinol – a potential inhibitor of the gonadotropic axis in sheep during lactation

This study tested the hypothesis that salsolinol, a derivative of dopamine, affects gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion in lactating sheep. In the in vivo experiment, the structural analogue of salsolinol, 1-methyl-3,4-dihydroisoquinoline (1-MeDIQ), was infused into the infundibular nucleus/median eminence (IN/ME) of sheep at the 5th wk of lactation to antagonize salsolinol ’s action. Simultaneously, cerebrospinal fluid from the third brain ventricle, to determine GnRH concentration, and plasma samples, to measure LH concentration, were collected.
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research