Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain

Conclusions: These findings show the differential time course of oxidative stress and inflammatory responses to nPM between the OE and the brain. Slow cumulative transport of inhaled nPM into the brain may contribute to delayed responses of proximal and distal brain regions, with potential input from systemic factors.

Citation: Cheng H, Saffari A, Sioutas C, Forman HJ, Morgan TE, Finch CE. 2016. Nanoscale particulate matter from urban traffic rapidly induces oxidative stress and inflammation in olfactory epithelium with concomitant effects on brain. Environ Health Perspect 124:1537–1546; http://dx.doi.org/10.1289/EHP134
Address correspondence to C.E. Finch, 3715 McClintock Ave., Gerontology-USC, Los Angeles, CA 90089-0191 USA. Telephone: [phone]. E-mail: [e-mail]
This work was supported by grants from the National Institute on Aging/National Institutes of Health (R21-AG040753, R21-AG040683, and R01-AG051521) and the Southern California Children’s Environmental Health Center (grants P30ES007048, P01ES022845, and EPA83544101).
The authors declare they have no actual or potential competing financial interests.
Received: 16 September 2015
Revised: 29 February 2016
Accepted: 2 May 2016
Published: 17 May 2016
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Source: EHP Research - September 30, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article October 2016 Source Type: research