Role of G protein-coupled estrogen receptor-1 in estradiol 17 β-induced alterations in protein synthesis and protein degradation rates in fused bovine satellite cell cultures

In feedlot steers, estradiol-17 β (E2) and combined E2 and trenbolone acetate (a testosterone analog) implants enhance rate and efficiency of muscle growth; and, consequently, these compounds are widely used as growth promoters in several countries. Treatment with E2 stimulates protein synthesis rate and suppresses protein degrad ation rate in fused bovine satellite cell (BSC) cultures; however, the mechanisms involved in these effects are not known with certainty. Although the genomic effects of E2 mediated through the classical estrogen receptors have been characterized, recent studies indicate that binding of E2 to the G protein-coupled estrogen receptor (GPER)-1 mediates nongenomic effects of E2 on cellular function.
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research