Atp1a2 Contributes Modestly to Alcohol-Related Behaviors

This study utilized Atp1a2 knockout mice; Atp1a2 heterozygous mice, with half the amount of protein compared to wild-type mice, were used because Atp1a2 homozygous null mice die shortly after birth. The alcohol-related behavioral experiments performed were loss of righting reflex (LORR), acute alcohol withdrawal measured by handling-induced convulsions (HIC), drinking in the dark (DID), open-field activity (OFA), and elevated plus-maze (EPM).

Source: Alcohol - September 28, 2016 Category: Addiction Authors: Stephanie M. Gritz, Colin Larson, Richard A. Radcliffe Source Type: research