Central skull base osteomyelitis involving cavernous sinus and meninges of the skull base: Successful treatment with antibiotic and antifungal combination therapy

Central skull base osteomyelitis (CSBO) is a rare and life-threatening infection [1]. Because the magnetic resonance imaging (MRI) of CSBO resembles central skull base neoplasm, and diagnosis is often difficult [1 –3], long-term systemic antimicrobial therapy has replaced surgical drainage as the first-line therapy for CSBO [3]. Here, we report a CSBO patient successfully treated with long-term ciprofloxacin and voriconazole without surgical intervention. Signal changes in the skull base bone marrow were ob served on diffusion-weighted images (DWI) during the course of illness.

Source: Clinical Neurology and Neurosurgery - September 28, 2016 Category: Neurosurgery Authors: Tatsuya Ueno, Haruo Nishijima, Rie Haga, Masahiko Tomiyama Tags: Case Report Source Type: research