Successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein-S deficiency and exogenous testosterone

Parameswaran Anoop, Vithal Malmande, MN Prakash Kumar, Naveen RaoIndian Journal of Plastic Surgery 2016 49(2):268-270Flap failure from microvascular thrombotic occlusion is a rare but significant cause for unsuccessful reconstructive surgery. We encountered thrombosis of arteriovenous loop in a patient undergoing phallus reconstruction. Further investigations revealed underlying previously asymptomatic hypercoagulable state due to protein-S deficiency in addition to long-term exogenous testosterone administration. Role of thrombophilia testing, thrombogenic potential of testosterone and the need for therapeutic perioperative anti-coagulation in such situations are described here.
Source: Indian Journal of Plastic Surgery - Category: Cosmetic Surgery Authors: Source Type: research