Regional tumour glutamine supply affects chromatin and cell identity

Nature Cell Biology 18, 1027 (2016). doi:10.1038/ncb3414 Authors: Jonas W. Højfeldt & Kristian Helin Limited perfusion of solid tumours produces a nutrient-deprived tumour core microenvironment. Low glutamine levels in the tumour core are now shown to lead to reduced levels of α-ketoglutarate and decreased histone demethylase activity, thereby promoting a less differentiated and more therapy-resistant state of the tumour cells.
Source: Nature Cell Biology - Category: Cytology Authors: Tags: News and Views Source Type: research