Turn up the lysosome

Nature Cell Biology 18, 1025 (2016).
doi:10.1038/ncb3409

Authors: Paul Saftig & Albert Haas
Lysosomes are digestive organelles of the endocytic and autophagic pathways. Increasing lysosome enzyme activities could help to clear pathological cellular waste. A recent study shows that lysosomal digestive functions can be promoted in isolated cells and mice by pharmacologically stimulating the autophagy- and lysosome-regulating transcription factors TFEB and ZKSCAN3 through previously unrecognized mTORC1-independent pathways acting via PKC.

Source: Nature Cell Biology - September 27, 2016 Category: Cytology Authors: Paul Saftig Albert Haas Tags: News and Views Source Type: research