The chemerin receptor 23 agonist, chemerin, attenuates monosynaptic C-fibre input to lamina I neurokinin 1 receptor expressing rat spinal cord neurons in inflammatory pain

Conclusions: These results suggest that the reported ability of ChemR23 agonists to attenuate inflammatory painhypersensitivity may in part be due to a presynaptic inhibition of monosynaptic C-fibre input to laminaI NK1R+ neurons and provides further evidence that ChemR23 represents a promising inflammatorypain target.

http://www.molecularpain.com/content/10/1/24

Source: Molecular Pain - April 9, 2014 Category: Molecular Biology Authors: Allen DickieCarole Torsney Source Type: research