Regulatory circuits of T cell function in cancer

Nature Reviews Immunology 16, 599 (2016). doi:10.1038/nri.2016.80 Authors: Daniel E. Speiser, Ping-Chih Ho & Grégory Verdeil Recent progress in cancer immunotherapy emphasizes the importance of understanding immune-regulatory pathways in tumours. Dysfunction of antitumour T cells may be due to mechanisms that are evolutionarily conserved or acquired by somatic mutations. The dysfunctional state of T cells has been termed 'exhaustion', on the
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research