Exogenous Fatty Acids and Niacin On Acute Prostaglandin D2 Production In Human Myeloid Cells

Niacin activates hydroxy-carboxylic acid receptor 2 (HCA2) receptor coupled to distal enzymes that results in the release of prostaglandin D2 (PGD2). However, little is known on PGD2-producing cells and the role of dietary fatty acids in the regulation of PGD2 production. With the exception of neutrophils and monocytes, all cells but notably M-CSF macrophages exhibited a timely dependent PGD2 production upon niacin challenge. Short pre-treatment of M-CSF macrophages with autologous postprandial triglyceride-rich lipoproteins (TRLs) induced the down-regulation of HCA2 gene and up-regulation of genes encoding cyclooxygenase isoform 1 (COX1) and COX2 enzymes in a fatty acid-dependent manner.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research