TPR Podcast Episode #12: 25 years of weird and wacky toxicology papers

25th Anniversary The Poison Review Podcast: Wild, Wacky and Weird Toxicology Articles From The Last Quarter-Century “It is universally well known, that in ingesting our common food, there is created or produced in the bowels of human creatures, a great quantity of wind.”  Benjamin Franklin Does Beano prevent gas? A double-blind crossover study of oral alpha-galactosidase to treat dietary oligosaccharide intolerance. Ganiats TG et al. J Fam Pract 1994 Nov;39:441-5. An air stewardess with puzzling diarrhoea. Greaves RR et al. Lancet 1996 Nov 30;348:1488 Lithium intoxication of unusual origin. Pristach CA. Psychosomatics 1987 Dec;28:632, 634 Hydrochlorate of Cocaine — Experiments and Application. Knapp H. The Medical Record October 25, 1884. Acute renal toxicity after ingestion of Lava light liquid. Erickson TB et al. Ann Emerg Med 1996 Jun;27:781-4.   Stool osmolar gap = 290 – 2*(stool Na + stool K)   [normal 50-100 mOsm/kg] If stool osmolar gap < 50, diarrhea is secretory If stool osmolar gap > 100, diarrhea is osmotic Osmotic diarrhea will resolve with fasting; secretory diarrhea will not Here is a link to a stool osmolar gap calculator   To read WebMD’s discussion of cases similar to that of the airline stewardess, click here.   NOTE: As indicated above, current thinking is that a normal stool osmolar gap is between 50 and 100 mOsm/kg. Interestingly, by that measure the stool osmolar gap in this case of the air stewardess with puzz...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical Podcast Source Type: news