Tetravalent DNA vaccines Product as a vaccines Candidate Against Dengue

Dengue is the most important arbovirus worldwide and is the virus that causes dengue fever and the more severe dengue hemorrhagic fever. There are four serotypes of dengue with each possessing the ability to cause disease. Developing a preventive vaccines is the most efficient and effective way to prevent these diseases, and because immunity to one serotype does not protect against the other serotypes, a vaccines must provide tetravalent protection. We used DNA immunization as a platform to develop a tetravalent vaccines. In this chapter, we describe the laboratory, regulatory, and clinical methodology for evaluating a candidate tetravalent vaccines in a Phase 1 clinical trial.
Source: Springer protocols feed by Immunology - Category: Allergy & Immunology Source Type: news