Insulin-like growth factor-related components and the risk of liver cancer in a nested case-control study

We examined relationships between serum levels of these factors and hepatoma risk in a case-control study nested in a prospective cohort study (the Japan Collaborative Cohort Study (JACC Study)). A baseline survey was conducted from 1988 to 1990, and 39,242 subjects donated blood samples. Participants diagnosed with hepatoma by 1997 were considered cases for nested case-control studies. Ninety-one cases and 263 sex- and age-matched controls were analyzed. A conditional logistic model was used to estimate odds ratios (ORs) for the incidence of hepatoma associated with serum IGF1 and IGFBP3 levels. Neither IGF1 nor the molar ratio of IGF1/IGFBP3 was correlated with hepatoma risk. After adjustment for hepatitis viral infection, body mass index, smoking, and alcohol intake, a higher molar difference of (IGFBP3  − IGF1) was associated with a decreased hepatoma risk more than IGFBP3 alone (p for trend<0.001 and = 0.003, respectively). People in the highest quartile had a lower risk (OR  = 0.098; 95 % confidence interval = 0.026–0.368). In subgroup analyses of males and females, the molar difference was associated with a decreased hepatoma risk (p for trend<0.05). In non-elderly individuals, the difference was inversely correlated with the incidence of hepatoma (p for trend<0.01). The molar difference of (IGFBP3  − IGF1) may be inversely associated with the incidence of hepatoma.
Source: Tumor Biology - Category: Cancer & Oncology Source Type: research