Endothelial-to-mesenchymal transition: Cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions

Endothelial-to-mesenchymal transition (EndMT) is a process by which endothelial cells (ECs) progressively lose endothelial features and gain mesenchymal fibroblast-like characteristics, transitioning from a differentiated to an undifferentiated state [1]. This phenomenon shares many features with the extensively described process of epithelial-to-mesenchymal transition (EMT), whereby epithelial cells lose expression of epithelial markers (e.g., E-cadherin, α-, β- and γ-catenin) and gain expression of mesenchymal proteins [e.g.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research