Human ULK1 Variation and Susceptibility to Mycobacterium tuberculosis Infection

Conclusions. These results demonstrate a strong association of rs12297124, a noncoding ULK1 SNP, with LTBI and a role for ULK1 regulation of TNF secretion, nonspecific and M. tuberculosis–induced autophagy, and M. tuberculosis replication in monocytes.

Source: The Journal of Infectious Diseases - September 22, 2016 Category: Infectious Diseases Authors: Horne, D. J., Graustein, A. D., Shah, J. A., Peterson, G., Savlov, M., Steele, S., Narita, M., Hawn, T. R. Tags: BACTERIA Source Type: research