Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria

Conclusions. We demonstrate that age, in addition to weight, is a determinant of lumefantrine exposure, and in the absence of trimethoprim-sulfamethoxazole, lumefantrine exposure is a determinant of recurrent parasitemia. Exposure levels in children aged 6 months to 2 years was generally lower than levels published for older children and adults. Further refinement of artemether-lumefantrine dosing to improve exposure in infants and very young children may be warranted.

Source: The Journal of Infectious Diseases - September 22, 2016 Category: Infectious Diseases Authors: Tchaparian, E., Sambol, N. C., Arinaitwe, E., McCormack, S. A., Bigira, V., Wanzira, H., Muhindo, M., Creek, D. J., Sukumar, N., Blessborn, D., Tappero, J. W., Kakuru, A., Bergqvist, Y., Aweeka, F. T., Parikh, S. Tags: PARASITES Source Type: research