Adaptation of Mycobacterium tuberculosis to Impaired Host Immunity in HIV-Infected Patients

Conclusions. M. tuberculosis in HIV-infected patients had lower expression of the DosR regulon, a critical metabolic and immunomodulatory switch induced by NO, carbon monoxide, and hypoxia. Our human data suggest that decreased DosR expression may result from alternative pathway activation of macrophages, with consequent decreased NO expression and/or by poor granuloma formation with consequent decreased hypoxic stress.

Source: The Journal of Infectious Diseases - September 22, 2016 Category: Infectious Diseases Authors: Walter, N. D., de Jong, B. C., Garcia, B. J., Dolganov, G. M., Worodria, W., Byanyima, P., Musisi, E., Huang, L., Chan, E. D., Van, T. T., Antonio, M., Ayorinde, A., Kato-Maeda, M., Nahid, P., Leung, A. M., Yen, A., Fingerlin, T. E., Kechris, K., Strong, Tags: HIV/AIDS Source Type: research