Comparison between serum level of superoxide dismutase, malondialdehyde, and DNA damage in acne vulgaris and vitiligo patients

Background: Free radical-mediated reactions and oxidative stress have been implicated in the pathogenesis of acne, but their role in eliciting this response and contributing to disease progress remains unexplored. Objective: To evaluate the extent of oxidative stress and DNA damage in patients with acne vulgaris in comparison with patients with vitiligo, a disease with a well-known and documented role of oxidative stress in its pathogenesis. Patients and methods: Serum from 15 patients with acne vulgaris, 15 patients with vitiligo, and 15 age-matched and sex-matched controls were evaluated for serum levels of superoxide dismutase (SOD), malondialdehyde (MDA), and DNA damage. Results: In both acne vulgaris and vitiligo patients, serum level of MDA and percentage of DNA damage were statistically significantly higher compared with controls (P
Source: Journal of the Egyptian Women’s Dermatologic Society - Category: Dermatology Tags: Original articles Source Type: research