Gene expression of FOXP3 and TGF-β1 in the blood of patients with mycosis fungoides, a hospital-based case–control study

Background: Regulatory T cells (Tregs) are FOXP3+ subpopulation of CD4+ T cells with transforming growth factor (TGF)-β1-mediated immunosuppressive effects. They play a role in the etiopathogenesis of various malignancies including cutaneous T-cell lymphomas. Objectives: To study the gene expression of FOXP3 and TGF-β1 in the blood of mycosis fungoides (MF) patients compared with controls. Patients and methods: Venous blood of 5 ml was taken from 25 MF patients and 25 healthy volunteers. Samples were subjected to real-time PCR for the measurement of FOXP3 and TGF-β1 mRNA expression. Results: Although FOXP3 mRNA levels were significantly higher in patients compared with controls, TGF-β1 mRNA levels were significantly lower (P
Source: Journal of the Egyptian Women’s Dermatologic Society - Category: Dermatology Tags: Original articles Source Type: research