Classification-based quantitative analysis of stable isotope labeling by amino acids in cell culture (SILAC) data

• A novel PSO classification-based approach to dealing with SILAC data is introduced.• It depends mainly on the protein ratio summary not restricted only to the proteins with two or more peptide hits.• No addition correction for multiple comparisons is necessary.• The developed methods are i mplemented in the R package cSILAC.

Source: Computer Methods and Programs in Biomedicine - September 21, 2016 Category: Bioinformatics Authors: Seongho Kim, Nicholas Carruthers, Joohyoung Lee, Sreenivasa Chinni, Paul Stemmer Source Type: research