Evaluating the effects of refined carbohydrate and fat diets with acute ethanol consumption using a mouse model of alcoholic liver injury

Alcoholism is a multifactorial and complex disorder responsible for 5.9% of deaths worldwide. Excessive consumption of ethanol (Et-OH) induces alcoholic liver disease (ALD), a condition comprising a spectrum of clinical signs and morphological changes, ranging from fatty liver (steatosis) to more severe forms of chronic liver injury. Secondary cofactors, such as nutritional and hepatotoxic co-morbid conditions, can also contribute to liver disease development. Here we investigated the effects in the progression of ALD following short term exposure to diets high in refined carbohydrates (HC), a high sugar and butter (HSB) hyper-caloric diet and acute Et-OH consumption.

Source: The Journal of Nutritional Biochemistry - September 21, 2016 Category: Biochemistry Authors: Juliana L. Gon çalves, Norinne Lacerda-Queiroz, Josiane F.L. Sabino, Pedro E. Marques, Izabela Galvão, Conrado O. Gamba, Geovanni D. Cassali, Luana M. de Carvalho, Daniel Almeida da Silva e Silva, Adaliene Versiani, Mauro M. Teixeira, Ana Maria Caetano Source Type: research