Eicosapentaenoic Acid Regulates Brown Adipose Tissue Metabolism in High Fat Fed Mice and in Clonal Brown Adipocytes

Brown adipose tissue (BAT) plays a key role in energy expenditure through its specialized thermogenic function. Therefore, BAT activation may help prevent and/or treat obesity. Interestingly, subcutaneous white adipose tissue (WAT) also has the ability to differentiate into brown-like adipocytes and may potentially contribute to increased thermogenesis. We have previously reported that eicosapentaenoic acid (EPA) reduces high fat (HF) diet-induced obesity and insulin resistance in mice. Whether BAT mediates some of these beneficial effects of EPA has not been determined.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research