Introduction to Advances in Inherited Cancers

For decades, clinicians and researchers have recognized families with an apparent “excess of cancers” and struggled with how to best treat their cancers and prevent additional tumors in at-risk relatives. Painstaking work using candidate gene studies, linkage analysis and positional cloning involving hundreds of families has led to the identification of literally dozens of ge nes implicated in inherited cancer susceptibility. While some of these genes have been implicated in the pathogenesis of relatively rare, highly-penetrant cancer syndromes (e.g.

Source: Seminars in Oncology - September 21, 2016 Category: Cancer & Oncology Authors: Elena Stoffel, Kathleen A. Cooney Source Type: research