Combination leflunomide and methotrexate in refractory rheumatoid arthritis: a biologic sparing approach

Conclusions: LEF/MTX was effective in the majority of patients in this cohort of mainly Black African women who failed other combination synthetic DMARDs, particularly in those with moderate disease activity at the time of addition of LEF. Infections and hypertension were important complications. In a setting where biologic DMARDs are not readily accessible, the combination of LEF/MTX is a cost-effective approach.
Source: Therapeutic Advances in Musculoskeletal Disease - Category: Orthopaedics Authors: Tags: Original Research Source Type: research