A Safety Evaluation of a Nature-Identical L-Ergothioneine in Sprague Dawley Rats

In conclusion, EGT+ administered over 90 days was well tolerated with a no adverse effect level at 1,600 mg/kg bw/d, the highest dose tested for male and female rats. In addition, the nature-identical test substance, EGT+ was not mutagenic in a bacterial reverse mutation assay at plate concentrations of up to 5,000 μg/mL in the presence or absence of metabolic activation.

Source: International Journal of Toxicology - September 20, 2016 Category: Toxicology Authors: Marone, P. A., Trampota, J., Weisman, S. Tags: Food Ingredient Safety Evaluation Source Type: research