Current Topics in Postnatal Behavioral Testing

This article summarizes the proceedings of a symposium held during the 2015 American College of Toxicology annual meeting and includes a discussion of the current status of DNT testing as well as potential issues and recommendations. Topics include the regulatory context for DNT testing; study design and interpretation; behavioral test selection, including a comparison of core learning and memory systems; age of testing; repeated testing of the same animals; use of alternative animal models; impact of findings; and extrapolation of animal results to humans. Integration of the regulatory experience and scientific concepts presented during this symposium, as well as from subsequent discussion and input, provides a synopsis of the current state of DNT testing in safety assessment, as well as a potential roadmap for future advancement.

Source: International Journal of Toxicology - September 20, 2016 Category: Toxicology Authors: Henck, J. W., Elayan, I., Vorhees, C., Fisher, J. E., Morford, L. L. Tags: ACT Annual Meeting Symposium Overview Articles Source Type: research